P220E Mercedes-benz 350 shows up when there's an electrical problem that causes the fuel volume regulator to malfunction and open. It's quite an unusual problem and likely intermittent. So if the problem persists despite of your diagnosis, then you should never hesitate to take your vehicle to your dealer or to a qualified mechanic.
Possible Causes :
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If all testing has passed so far yet you still have the same code, check your scan tool and see if it can open and close the IMRC valve. With the valve disconnected, the red voltmeter lead should be attached to the IMRC valve power wire and the black voltmeter lead connected to ground.
Diagnostic trouble code P220E Mercedes-benz 350 is not difficult to diagnose and repair. Thus, it always pays to have a qualified technician to look after your vehicle should this error code arise.
Diagnosing this code requires the engine to be in good running shape, without unmetered air entering the engine. If other codes that relates to misfiring condition, lean running or air entering the engine is present, then you must first fix those error codes before P220E Mercedes-benz 350.
Fortunately, P220E Mercedes-benz 350 is a fairly common OBD code, meaning that it applies to all makes and models of vehicles made after 1996.