P0421 Mercedes Cl 500 is described as Fuel Rail Pressure Sensor Circuit Malfunction. This code is strictly about the incoming signal from the FRP (fuel rail pressure) sensor falling below the calibrated limit for a certain period of time. So if the problem persists despite of your diagnosis, then you should never hesitate to take your vehicle to your dealer or to a qualified mechanic.
Possible Causes :
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Replace the oxygen sensor that is downstream from the catalytic converter on the side of the engine that does not contain cylinder #1. Also, if a oxygen sensor code stating "heater circuit malfunction" the sensor has most probably failed. Look for missing ground strap or a rusty ground where the fuel tank is grounded to the frame. Check for damage to the wiring harness connector. Pack the connector cavity with dielectric silicone compound (same stuff they use for light bulb sockets and spark plug wires) and reassemble.
Diagnostic trouble code P0421 Mercedes Cl 500 is not difficult to diagnose and repair. Thus, it always pays to have a qualified technician to look after your vehicle should this error code arise.
Diagnosing this code requires the engine to be in good running shape, without unmetered air entering the engine. If other codes that relates to misfiring condition, lean running or air entering the engine is present, then you must first fix those error codes before P0421 Mercedes Cl 500.
Fortunately, P0421 Mercedes Cl 500 is a fairly common OBD code, meaning that it applies to all makes and models of vehicles made after 1996.