C0043 Lexus Is300 shows up when there's an electrical problem that causes the fuel volume regulator to malfunction and open. It's quite an unusual problem and likely intermittent. The spark should have a light tan color. If the sensor probe comes with white and chalky parts, this means it has been lagging between switching phases, and should be replaced.
Possible Causes :
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Now, clear the codes and test-drive the vehicle to see if the code is reset. With the valve disconnected, the red voltmeter lead should be attached to the IMRC valve power wire and the black voltmeter lead connected to ground. Look at the plug wires to make sure they are not burnt or laying on the exhaust.
Diagnostic trouble code C0043 Lexus Is300 is not difficult to diagnose and repair. Thus, it always pays to have a qualified technician to look after your vehicle should this error code arise.
Diagnosing this code requires the engine to be in good running shape, without unmetered air entering the engine. If other codes that relates to misfiring condition, lean running or air entering the engine is present, then you must first fix those error codes before C0043 Lexus Is300.
Fortunately, C0043 Lexus Is300 is a fairly common OBD code, meaning that it applies to all makes and models of vehicles made after 1996.