B2161 Mercedes S 63 is defined as Knock Sensor Circuit Range Performance (Bank 1 or Single Sensor). This refers to camshaft timing, which in this case is over-retarded. If the car doesn't start, they will proceed by testing the voltage at the fuel pump connector and see if the fuel pump relay, fuse, and PCM circuitry should be inspected.
Possible Causes :
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With the valve disconnected, the red voltmeter lead should be attached to the IMRC valve power wire and the black voltmeter lead connected to ground. Use the DVOM to test resistance and continuity on all system circuits if actuator and sensor resistance levels are in compliance with manufacturer's specifications.
Diagnostic trouble code B2161 Mercedes S 63 is not difficult to diagnose and repair. Thus, it always pays to have a qualified technician to look after your vehicle should this error code arise.
Diagnosing this code requires the engine to be in good running shape, without unmetered air entering the engine. If other codes that relates to misfiring condition, lean running or air entering the engine is present, then you must first fix those error codes before B2161 Mercedes S 63.
Fortunately, B2161 Mercedes S 63 is a fairly common OBD code, meaning that it applies to all makes and models of vehicles made after 1996.