C0721 Ford F-450 shows up when there's an electrical problem that causes the fuel volume regulator to malfunction and open. It's quite an unusual problem and likely intermittent. If the car doesn't start, they will proceed by testing the voltage at the fuel pump connector and see if the fuel pump relay, fuse, and PCM circuitry should be inspected.
Possible Causes :
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Replace the oxygen sensor that is downstream from the catalytic converter on the side of the engine that does not contain cylinder #1. Also, if a oxygen sensor code stating "heater circuit malfunction" the sensor has most probably failed. With the valve disconnected, the red voltmeter lead should be attached to the IMRC valve power wire and the black voltmeter lead connected to ground. It should be pretty close to battery voltage (12 volts). If not, then this is the circuit that has the problem.
Diagnostic trouble code C0721 Ford F-450 is not difficult to diagnose and repair. Thus, it always pays to have a qualified technician to look after your vehicle should this error code arise.
Diagnosing this code requires the engine to be in good running shape, without unmetered air entering the engine. If other codes that relates to misfiring condition, lean running or air entering the engine is present, then you must first fix those error codes before C0721 Ford F-450.
Fortunately, C0721 Ford F-450 is a fairly common OBD code, meaning that it applies to all makes and models of vehicles made after 1996.